GLP-1 analogs oral
Glucagon Like Peptide - 1 (GLP-1), a 30 amino acid amidated peptide hormone, is secreted from gut endocrine cells in response to nutrient ingestion and plays multiple roles in metabolic homeostasis. It stimulates insulin secretion and simultaneously decreases the secretion of glucagon. GLP-1 may represent an ideal treatment for type 2 diabetes, since its insulinotropic effect is glucose dependent, and treatment with this hormone may present a low risk of hypoglycemia. GLP-1 may also decrease hepatic glucose production indirectly, delay gastric emptying, and act as an appetite suppressant in diabetics. Recent evidence suggests that the hormone stimulates the differentiation of islet progenitor cells into insulin-producing cells and may be important for β-cell neogenesis.
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