CGRP
Calcitonin Gene-Related Peptide (CGRP) is a nonadrenergic/noncholinergic 37 amino acid amidated peptide that coexists with Substance P and Neurokinin A in sensory nerve cell bodies, i.e., the dorsal root ganglia. CGRP is the most abundant of all neuropeptides in human skin and is a potent endogenous vasodilator of the microcirculation.
CGRP circulates in normal subjects at relatively high concentrations (approximately 25 pmol) and is present in perivascular tissues, indicating a possible role for CGRP in controlling peripheral vascular tone in human skin. The peptide has also been shown to produce a dose-dependent increase in vasodilation. The long-lasting and widespread vascular effects of CGRP may reflect gradual diffusion of the peptide which may exert its actions on both the endothelium and vascular smooth muscles. Recent studies have shown that due to its vasodilation action CGRP may be a potent treatment for congestive heart failure.
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